RB Leipzig vs Bayer Leverkusen Prediction, December 21 – A Fiery Heavyweight Clash Set to Ignite the Bundesliga

Prediction, the result forecast of RB Leipzig vs Bayer Leverkusen, RB Leipzig will host Bayer Leverkusen at home in of the German Bundesliga. Expert opinions, predictions, expert analysis, match odds information, pre-match sideline stadium.

RB Leipzig

German Bundesliga

00:30 12/21/2025

-Venue: Red Bull Arena

Bayer Leverkusen

Prediction soccer results RB Leipzig vs Bayer Leverkusen

Tips

Asian Handicap:RB Leipzig -0.25

Score:3 - 2

Over/Under: Over 3

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Expert Opinion:

RB Leipzig vs Bayer Leverkusen Review

In terms of their historical head-to-head record, RB Leipzig is currently the underrated team. Out of their last 10 matches, RB Leipzig 4 wins, only 2 draws, while Bayer Leverkusen win 4, giving RB Leipzig a win rate of 40.00%. The average number of goals scored in their meetings is 3.10. In their most recent encounter, which was held at RB Leipzig home stadium, RB Leipzig draw with a score of 2-2.

RB Leipzig

In their last 5 matches across all venues, RB Leipzig won 3 match, draw 1 and lost 1. RB Leipzig offense scored 12 goals and their defense conceded 4 goals in this period. RB Leipzig win rate is 60.00%, their Asian Handicap win rate is 50.00%, and the Over rate is 60.00%. In the 3 matches played at home, RB Leipzig won 3/3 match, scoring 11 goals and conceding 1 goals.

Bayer Leverkusen

In their last 5 matches across all venues, Bayer Leverkusen won 2, draw 1 and lost 2. Bayer Leverkusen offense scored 6 goals and their defense conceded 6 goals in this period. Bayer Leverkusen win rate is 40.00%, their Asian Handicap win rate is 60.00%, and the Over rate is 30.00%. In the 2 matches played as away, Bayer Leverkusen won 1/2 match, scoring 1 goals and conceding 2 goals.

Odds rate RB Leipzig vs Bayer Leverkusen

Time	Match	Fulltime			Halftime
Time	Match	Asian Handicap	Over/Under	1x2	Asian Handicap	Over/Under	1x2
LIVE	RB Leipzig	0.250.93	30.85	2.20	00.70	1.250.90	2.63
	Bayer Leverkusen	0.93	1.00	3.00	1.10	0.90	3.40
	Draw			3.75			2.40

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Force Information

Line-ups and substitutes RB Leipzig vs Bayer Leverkusen

RB Leipzig 4-3-3

Gulacsi P.

Raum D.

Lukeba C.

Orban W.

K.Nedeljković

Schlager X.

Seiwald N.

A.Maksimović

Baumgartner C.

C.Harder

T.Gomis

Bayer Leverkusen 3-4-2-1

Schick P.

Hofmann J.

Tella N.

Arthur

Garcia A.

Tillman M.

Grimaldo A.

Bade L.

Andrich R.

Belocian J.

Flekken M.

Injuries and suspensions

RB Leipzig

Injuries

Suspensions

Bote Baku

Forzan Assan...

Benjamin Henrichs

Yan Diomande

Bayer Leverkusen

Injuries

Suspensions

Eliesse Ben...

Alex Grimaldo

Exequiel Palacios

Jarell Quansah

Ibrahim Maza

Confrontation history RB Leipzig vs Bayer Leverkusen

Date	League	Home	Score	HT	Corner	Away
01/25/2025 GER D1	GER D1	RB Leipzig	2-2	1-2	7-3	Bayer Leverkusen
08/31/2024 GER D1	GER D1	Bayer Leverkusen	2-3	2-1	18-2	RB Leipzig
01/21/2024 GER D1	GER D1	RB Leipzig	2-3	1-0	1-9	Bayer Leverkusen
08/19/2023 GER D1	GER D1	Bayer Leverkusen	3-2	2-1	4-5	RB Leipzig
04/23/2023 GER D1	GER D1	Bayer Leverkusen	2-0	1-0	0-9	RB Leipzig
10/29/2022 GER D1	GER D1	RB Leipzig	2-0	1-0	3-3	Bayer Leverkusen
04/18/2022 GER D1	GER D1	Bayer Leverkusen	0-1	0-0	7-1	RB Leipzig
11/28/2021 GER D1	GER D1	RB Leipzig	1-3	0-2	7-2	Bayer Leverkusen
01/31/2021 GER D1	GER D1	RB Leipzig	1-0	0-0	6-6	Bayer Leverkusen
09/26/2020 GER D1	GER D1	Bayer Leverkusen	1-1	1-1	4-1	RB Leipzig

Performance of the last 5 matches

RB Leipzig

League	Home	Score	Away
12/13/2025 GER D1	Union Berlin	3-1	RB Leipzig
12/07/2025 GER D1	RB Leipzig	6-0	Eintracht Frankfurt
12/03/2025 GERC	RB Leipzig	3-1	Magdeburg
11/29/2025 GER D1	Borussia Monchengladbach	0-0	RB Leipzig
11/23/2025 GER D1	RB Leipzig	2-0	Werder Bremen

Statistics of form:

Bayer Leverkusen

League	Home	Score	Away
12/14/2025 GER D1	Bayer Leverkusen	2-0	FC Koln
12/11/2025 UEFA CL	Bayer Leverkusen	2-2	Newcastle United
12/06/2025 GER D1	Augsburg	2-0	Bayer Leverkusen
12/03/2025 GERC	Borussia Dortmund	0-1	Bayer Leverkusen
11/30/2025 GER D1	Bayer Leverkusen	1-2	Borussia Dortmund